Physiological Ph Articles & Analysis
8 articles found
The operation of enzymes at ambient temperature and physiological pH offers a distinct advantage. It curtails energy consumption and reduces the dependency on extreme process conditions, which often necessitate additional safety and environmental measures. ...
Self-assembled hydrogels The fluidity of collagen hydrogels is primarily due to their high liquid phase, as well as their fast assembly time at physiological pH and temperature, making them ideal carriers for injectable systems and cellular and therapeutic/bioactive molecules. ...
Ergothioneine is a natural product found widely in various organisms, especially in ergot, where it is present in higher amounts. At physiological pH, ergothioneine is stable since it mainly exists in the form of thione. It possesses various physiological functions, including scavenging free radicals, detoxification, maintaining DNA biosynthesis, ...
Among them, arginine contains a guanidine group, which is hydrogen-bonded to negatively charged phosphate groups on the cell membrane and mediates CPPs entry into the membrane at physiological PH. Studies on oligo-arginine (from 3 R to 12 R) showed that the membrane penetration capacity was increased when the amount of arginine was at least 8, and the membrane ...
Polymers can bind with nucleic acids to form polycomplexes at physiological pH, facilitating gene delivery. Typically, polymer nanoparticles contain positively charged units that promote electrostatic binding with nucleic acids. ...
Cleavable linkers' performance thus hinges on their capacity to effectively distinguish between target cell circumstances and blood circulation conditions.Chemically Cleavable LinkerThere are three main types of chemically induced cleavable linkers: acid cleavable, cleavable under reducing conditions (disulfide, etc.), and linkers that can be cleaved by exogenous stimuli.l Acid-cleavable ...
In addition, the scientists also evaluated the effect of deacetylation and pH on the antibacterial behavior of biomolecules, and found that the antibacterial efficiency was highest when the deacetylation and pH were lower. ...
Hydrazones should stay stable in the circulation at physiological pH and undergo selective hydrolysis following internalization under acidic circumstances, theoretically. ...