Platelet Function Articles & Analysis
4 articles found
Platelet drug delivery systems will use platelets or their derivatives for creating specific drug carriers which can target matching cells to execute drug delivery functions and develop new treatment strategies. ...
This is based on the well-established evidence that approximately 30-50% of patients carry loss-of-function mutations for the CYP2C19 enzyme responsible for Clopidogrel bioactivation. ...
Assays are designed with the use of platelet rich citrated plasma, or with washed platelets. Platelet donors need to be characterized and selected, as there is an important donor's variability for platelets' activation by heparin dependent antibodies. FcyRIIA (CD32) platelet surface density and polymorphism (His ...
Many of the heparin dependent antibodies, including those with the IgG isotype, are asymptomatic, and only a subgroup of antibodies is positive in platelet activation assays. What differentiates pathogenic from asymptomatic antibodies is not fully understood, with the exception that there is some relationship between antibody concentration and occurrence of HIT, and that ...