Thyroid Hormone Articles & Analysis
34 articles found
Although snoring is usually considered as a harmless annoyance, it is actually a symptom of deeper health issues, such as hypothyroidism. This is when the thyroid reduces the production of thyroid, a vital hormone and there is a deficiency in the body. Though the connection between hypothyroidism and snoring isn’t obvious, there have been ...
Anorexia, a condition characterized by a significant reduction in food intake despite negative energy balance, poses severe risks to health and quality of life. It manifests in various forms in humans, including anorexia nervosa and physiological anorexia. While psychological and social factors have been widely studied, the physiological causes remain less understood. For ground squirrels, ...
Introduction of TSH The Thyroid-Stimulating Hormone (TSH) protein is a crucial player in the regulation of thyroid function. ...
Related Link: The Daily Biotech Pulse: Erytech Jumps On Fast Track Designation, GlaxoSmithKline FDA Nod, Alnylam's Clinical Collaboration, 4 IPOs Rani's Pipeline: Rani has a candidate codenamed RT-10 in Phase 1 development for acromegaly, a hormonal disorder. The company has five preclinical compounds evaluated for different indications. ...
The most intensively investigated of the PFAS family, perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS), have also been linked to cancer (PFOA) and thyroid hormone disruption (PFOS). One of the feature the PFAS family members share – their carbon-fluorine bond – imparts high thermal stability and resistance to degradation, ...
Butel listed some of the studied health risks of PFOA and PFOS compounds: Higher than normal incidence of cancer Liver enlargement Hormonal changes Thyroid function Elevated cholesterol Reduced birth weight Structural defects Increased neonatal deformities Butel said the good news is that the longer chain compounds linked to these health risks have ...
Iodine has a direct impact on growth rates as it is incorporated into the thyroid hormones which control metabolism, promoting efficient live weight gain. ...
Polybrominated diphenyl ethers (PBDEs) and their metabolites (e.g. hydroxylated BDEs (OH‐BDEs)) are contaminants detected together frequently in human tissues, and are structurally similar to thyroid hormones (TH). THs partially mediate metamorphic transitions between life stages in zebrafish, making this a critical developmental window which may be vulnerable ...
Deiodinases, a class of enzymes catalyzing thyroid hormone conversion, have been suggested to be involved in BDE‐209 debromination in birds. ...
Several PBDE congeners are considered thyroid disruptors however avian studies are limited. Here, we examined circulating thyroid hormones, thyroid gland function of nestling American kestrels (Falco sparverius) at 17‐20 d of age, following embryonic exposure by maternal transfer only to environmentally relevant levels of PBDEs ...
In the present study, BPS was injected into the air cell of unincubated, fertilized chicken embryos at 6 concentrations ranging from 0 to 207 µg/g egg to determine effects on pipping success, development, hepatic mRNA expression, thyroid hormone levels, and circulating bile acid concentrations. BPS concentrations increased in a dose‐dependent manner in whole ...
EPA's Endocrine Disruptor Screening Program (EDSP), initiated in 1998, employs a two-tier testing approach: Tier 1 screening is intended to identify substances with potential to interact with estrogen, androgen, or thyroid hormone systems; Tier 2 testing is intended to establish a dose-response relationship for any adverse effects that may have been first ...
Adult female mink and a subsequent F1 generation were exposed to Aroclor 1268 through diet, and effects on enzyme induction, histopathology, thyroid hormone regulation, hematology, organ weights, and body condition index were compared to a negative control and a 3,3',4,4',5‐pentachlorobiphenyl (PCB 126) positive control. ...
MicroRNAs are recently discovered small regulatory molecules that control messenger RNA (mRNA) translation in plants and animals and have been implicated in a variety of hormone‐related physiological pathways. Estrogens, thyroid hormones, and gonadotropins all are known to act on miRNA abundance to cause major shifts in cellular activity, ...
Microcystin‐LR (MC‐LR) has the potential to disturb thyroid hormone (TH) homeostasis, but little is known of the underlying mechanisms of MC‐LR in fish. ...
During the first trimester of pregnancy, the fetus is not making its own thyroid hormone, says Thomas Zoeller, director of the Laboratory of Molecular, Cellular and Developmental Endocrinology at the University of Massachusetts Amherst. If an environmental exposure to a substance such as a polychlorinated biphenyl or perchlorate interferes with the mother’s ...
ByEnsia
Avian studies of endocrine disruption have focussed traditionally on reproductive impairment given that many environmental contaminants affect sex steroid hormones. There is also increasing interest in altered thyroid function, and associated early development, particularly in altricial species with extended developmental windows. ...
In contrast, the PPCP mixture down‐regulated vtg in females and males, and expression of erα (estrogen receptor alpha), star, and thra1 (thyroid hormone receptor alpha 1) in testes. Our results show the molecular ‘estrogenic’ effects of triclocarban are eliminated (males) or reversed (females) when dosed in conjunction with several other PPCPs, once again showing ...
The avian embryonic hepatocyte in vitro screening method has been utilized by our laboratory to assess the effects of a wide range of environmental contaminants on (i) cytotoxicity and (ii) mRNA expression of genes associated with xenobiotic metabolism, the thyroid hormone pathway, lipid metabolism, and growth. Sixteen structurally variable organic flame ...
The effects of PCP exposure on plasma thyroid hormone levels, and the expression levels of selected genes, were measured in the brain and liver. ...