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The four living species of horseshoe crabs face a set of growing threats to their survival, including the erosion and/or man-made alteration of essential spawning habitat, coastal pollution, and overfishing. Horseshoe crabs are “living fossils”, with a more than 200 million year evolutionary history. Their blood provides a reagent, known as Limulus amebocyte lysate or LAL, that clots in the ...