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Rna Interference Equipment & Supplies
22 equipment items found
Manufactured by:OriGene Technologies, Inc. based inRockville, MARYLAND (USA)
Trilencer-27 siRNA kits contain Dicer-Substrate duplexes that provide two critical improvements over the use of traditional 21mer siRNA designs. It takes advantage of the natural processing by Dicer to produce 10-fold higher potency and specificity than shorter 21-mer siRNA forms. The 27-mer duplexes also evade mammalian interferon response when expressed in mammalian cells and initiate strong ...
Manufactured by:OriGene Technologies, Inc. based inRockville, MARYLAND (USA)
OriGene uses a 29-mer short hairpin design for Hush-29TM shRNA plasmids, which has been demonstrated to be more effective than 21-mer designs (learn more about the design algorithm). Pre-designed Hush-29 shRNAs offer genome-wide coverage for human, mouse and rat genes with a guaranteed knockdown of ≥70%. View ...
Manufactured by:OriGene Technologies, Inc. based inRockville, MARYLAND (USA)
OriGene offers pre-made lentiviral shRNA plasmid kits containing 4 sequence-verified expression cassettes that target your gene of interest. Each lentiviral cassette contains three major functional elements: shRNA, a puromycin selection marker & a tGFP reporter. With a guaranteed knockdown of ≥70%, these kits and our ready-to-use lenti-shRNA particles are a great option for studying ...
Manufactured by:Biosettia Inc. based inSan Diego, CALIFORNIA (USA)
The shRNA expression is suppressed by Tet repressor (TetR) binding to the hybrid H1 promoter containing tetracycline operators (TetO) and RNA interference only takes place in the presence of tetracycline. The inducible RNAi system provides the option of expressing shRNA in certain period of ...
Manufactured by:Biosettia Inc. based inSan Diego, CALIFORNIA (USA)
The shRNA expression is suppressed by Tet repressor (TetR) binding to the hybrid H1 promoter containing tetracycline operators (TetO) and RNA interference only takes place in the presence of tetracycline. The inducible RNAi system provides the option of expressing shRNA in certain period of ...
by:CIS Pharma AG based inBubendorf, SWITZERLAND
RNA interference (RNAi) is a mechanism used to defend against external invasion. Oligo- and poly-nucleotide based RNAi therapeutics comprise a high clinical potential for unmet medical diseases and are seen as promising approach to combat a number of different indications including oncology, genetic disorders, auto-immune disorders, orphan diseases and viral ...
Manufactured by:MedChemExpress LLC (MCE) based inMonmouth Junction, NEW JERSEY (USA)
Lumasiran sodium, an investigational RNA interference (RNAi) therapeutic agent, reduces hepatic oxalate production by targeting glycolate oxidase. Lumasiran sodium reduces urinary oxalate excretion, the cause of progressive kidney failure in primary hyperoxaluria type 1 (PH1) ...
Manufactured by:MedChemExpress LLC (MCE) based inMonmouth Junction, NEW JERSEY (USA)
Nedosiran (DCR-PHXC) is an RNA interference (RNAi) targeting lactate dehydrogenase (LDH). Nedosiran represents an impactful potential therapeutic for primary hyperoxaluria (PH) with end-stage renal disease (ESRD). Nedosiran is a GalNAc-dsRNA ...
Manufactured by:Scopus BioPharma based inNew York, NEW YORK (USA)
CO-sTiRNA™ is a highly selective and targeted gene therapy that silences the activity of the STAT3 gene by way of RNA interference. CO-sTiRNA™ also stimulates TLR9 receptors to activate the body’s immune defense to recognize and kill cancer ...
Manufactured by:Aquaintech Inc. (AITI) based inLynnwood, WASHINGTON (USA)
The fossil record shows that shrimp have been close to their current form for upwards of 350 million years. Clearly shrimp are high evolved and have developed a variety of mechanisms to ensure survival. Shrimp are invertebrates. They have no spine and their skeletons are outside of their bodies, unlike vertebrates that have an internal spinal column and whose skeletons are internal. Vertebrates ...
Manufactured by:MedChemExpress LLC (MCE) based inMonmouth Junction, NEW JERSEY (USA)
Lumasiran (ALN-G01), a siRNA product, reduces hepatic oxalate production by targeting glycolate oxidase. By silencing the gene encoding glycolate oxidase, Lumasiran depletes glycolate oxidase and thereby inhibits the synthesis of oxalate, which is the toxic metabolite that is directly associated with the clinical manifestations of Primary hyperoxaluria type 1 ...
Manufactured by:MedChemExpress LLC (MCE) based inMonmouth Junction, NEW JERSEY (USA)
Patisiran sodium is a double-stranded small interfering RNA that targets a sequence within the transthyretin (TTR) messenger RNA. Patisiran sodium specifically inhibits hepatic synthesis of mutant and wild-type TTR. Patisiran sodium can be used for the research of hereditary TTR ...
Manufactured by:MedChemExpress LLC (MCE) based inMonmouth Junction, NEW JERSEY (USA)
(R)-Baclofen hydrochloride (Arbaclofen hydrochloride) is a selective GABAB receptor ...
Manufactured by:MedChemExpress LLC (MCE) based inMonmouth Junction, NEW JERSEY (USA)
ZINC00640089 is a specific Lipocalin-2 (LCN2) inhibitor. ZINC00640089 inhibits cell proliferation, cell viability and reduces AKT phosphorylation levels in SUM149 cells. ZINC00640089 has good potential for research in inflammatory breast cancer ...
Manufactured by:MedChemExpress LLC (MCE) based inMonmouth Junction, NEW JERSEY (USA)
Enoxacin (AT 2266), a fluoroquinolone, interferes with DNA replication and inhibits bacterial DNA gyrase (IC50=126 µg/ml) and topoisomerase IV (IC50=26.5 µg/ml). Enoxacin is a miRNA processing activator and enhances siRNA-mediated mRNA degradation and promotes the biogenesis of endogenous miRNAs. Enoxacin has potent activities against gram-positive and -negative bacteria. ...
Manufactured by:MedChemExpress LLC (MCE) based inMonmouth Junction, NEW JERSEY (USA)
Enoxacin hydrate (Enoxacin sesquihydrate), a fluoroquinolone, interferes with DNA replication and inhibits bacterial DNA gyrase (IC50=126 μg/ml) and topoisomerase IV (IC50=26.5 μg/ml). Enoxacin hydrate is a miRNA processing activator and enhances siRNA-mediated mRNA degradation and promotes the biogenesis of endogenous miRNAs. Enoxacin hydrate has potent activities against ...
Manufactured by:MedChemExpress LLC (MCE) based inMonmouth Junction, NEW JERSEY (USA)
GNE-617 is a specific NAMPT inhibitor that inhibits the biochemical activity of NAMPT with an IC50 of 5 nM and exhibits efficacy in xenograft models of cancer. ...
Manufactured by:MedChemExpress LLC (MCE) based inMonmouth Junction, NEW JERSEY (USA)
SU 5402 is a potent multi-targeted receptor tyrosine kinase inhibitor with IC50 of 20 nM, 30 nM, and 510 nM for VEGFR2, FGFR1, and PDGFRβ, ...
Manufactured by:MedChemExpress LLC (MCE) based inMonmouth Junction, NEW JERSEY (USA)
SMI-16a is a selective Pim kinase inhibitor with IC50 values of 0.15, 0.02 and 48 μM for Pim1, Pim2 and PC3 cells, ...
Manufactured by:MedChemExpress LLC (MCE) based inMonmouth Junction, NEW JERSEY (USA)
GW9508 is a potent and selective G protein-coupled receptors FFA1 (GPR40) and GPR120 agonist with pEC50s of 7.32 and 5.46, respectively. GW9508 shows ~100-fold selectivity for GPR40 over GPR120. GW9508 is inactive against other GPCRs, kinases, proteases, integrins and PPARs. GW9508 is a glucose-sensitive insulin secretagogue and an ATP-sensitive potassium (KATP) channels opener. Anti-inflammatory ...