CD Formulation - Bacterial Endotoxin Testing

Bacterial Endotoxin Testing: Bacterial endotoxin is a complex of lipopolysaccharide (LPS) and protein in the cell wall of gram-negative bacteria, which is released when the bacteria die or autolysis. A large amount of endotoxin enters the bloodstream and causes a febrile reaction - a "pyrogenic reaction". If endotoxin enters and collects in the blood in large quantities and exceeds the clearance capacity of the body's self-defense system, endotoxemia of different degrees may result. Therefore, biological products, pharmaceuticals for injection, chemicals, radiopharmaceuticals, antibiotics, vaccines, dialysis solutions and other preparations, as well as medical devices (such as disposable syringes and implantable biological materials) must be tested for bacterial endotoxin before use.