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by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Nanoparticles (NPs), owing to their unique physical, chemical, and biological properties such as controllable size, tunable surface properties, and excellent biocompatibility, have been widely utilized in various fields including cosmetics, food packaging, energy production, and biosensing. Upon release into the environment and subsequent exposure to biological organisms via respiration, ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
The protein corona of nanoparticles exhibits several advantageous properties. Firstly, it can selectively enrich or deplete specific proteins within the corona, independently of the protein composition present in biological fluids. This capability is particularly beneficial for protein identification and characterization, especially within the realm of plasma proteomics. Secondly, the composition ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
There are primarily two methods for evaluating antibody coverage: 2D Western blot or Antibody Affinity Extraction (AAE). In the production and purification of therapeutic recombinant proteins expressed by cultured mammalian cells, contamination by HCPs is a potential issue. Every validation and quality control test of therapeutic proteins should include an assay to demonstrate HCP contamination ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Ideally, any technology for detecting Host Cell Proteins (HCPs) should: (i) detect protein concentrations across a wide dynamic range, from very low to much higher concentrations of impurity proteins; (ii) track changes in HCP populations and concentrations throughout the entire bioprocess; (iii) simultaneously monitor and measure multiple protein analytes; and (iv) detect low concentration HCPs ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Commercial ELISA kits play a crucial role in the preliminary phases of drug development. These kits are applicable to drugs already on the market, provided that their detection methodologies have undergone specific process performance ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Monoclonal antibodies (mAbs) are monovalent proteins expressed by B cells, capable of precisely targeting 3D epitopes, which makes it a compelling therapeutic option. Over 70 monoclonal antibody drugs have received FDA approval. Monoclonal antibody drugs dramatically transform modern medicine by offering targeted treatments for a variety of diseases. These antibodies specifically activate immune ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Antibodies (Abs) are essential components of the adaptive immune system, which can combat infections and other harmful agents. Produced by B cells, Ab is either secreted or expressed on the plasma membrane at the present of B cell receptors (BCRs). Each Ab comprises two heavy chains (VH) and two light chains (VL). The VL each include a constant region varing only across different classes and ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
The inauguration of monoclonal antibodies (mAbs), derived from mice, were immunogenic in humans. These molecules were first synthesized in 1975 by Georges Köhler and César Milstein through the use of hybridoma technology. Later, in 1984, another milestone was achieved with the production of chimeric human antibodies via recombinant DNA technology. Hybridoma technology facilitates the creation of ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Biopharmaceuticals, drugs produced by living cells, have revolutionized the treatment of various diseases since Eli Lilly and Company's introduction of the first human recombinant protein, Humulin (human insulin), in 1982. To date, over 200 biopharmaceuticals have been approved, encompassing hormones, growth factors, blood factors, vaccines, and monoclonal antibodies (mAbs), with mAbs being the ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Acetyl-CoA, an activated form of acetate, is formed by an acetyl group (CH3CO-) bonding to the thiol group of coenzyme A via a high-energy thioester bond. It is product of the decarboxylation of pyruvate produced by β-oxidation and glycolysis of fatty acid (FA). In the initial step of the tricarboxylic acid cycle (TAC), the acetyl group is transferred to oxaloacetate to form citrate, and this ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
One of the main obstacles in drug development is how to deliver drugs effectively to target cells. In general, macromolecules such as proteins and mRNA cannot penetrate the cell membrane because the cell membrane has acquired protective mechanisms through evolution. However, viruses can deliver their genetic material into cells. Therefore, viruses and virus-like particles are widely used to ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
MtoZ Biolabs has developed a high-resolution mass spectrometry, coupled with pLink-SS software, to provide our customers with accurate analysis of disulfide bonds and free ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
MtoZ Biolabs offers metallomics analysis service using ICP-MS, with high accuracy, specificity, and sensitivity. ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
MtoZ Biolabs offers tryptophan analysis service using an LC-MS-based MRM technology, with high accuracy, specificity, and sensitivity. ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
MtoZ Biolabs offers polyphenol analysis service using an LC-MS-based MRM technology, with high accuracy, specificity, and sensitivity. ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
MtoZ Biolabs offers targeted bioamine analysis service using UPLC/TripleQuad5500, with high accuracy, specificity, and sensitivity. ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
MtoZ Biolabs offers targeted organic acids analysis service using GC/MS, with high accuracy, specificity, and sensitivity. ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
MtoZ Biolabs offers targeted aldehydes analysis service using UPLC/TripleQuad5500, with high accuracy, specificity, and ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
MtoZ Biolabs have developed a LC-MS/MS system, which is suitable for analyzing both N- and C-terminal amino acid sequence and ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
MtoZ Biolabs has established an innovative EpiLink™ technical platform, which can outline the overall protein architecture via identifying direct binding partners and localizing the binding ...