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Drug Interaction Services
28 services found
Manufactured by:Newcells Biotech Limited based inNewcastle Upon Tyne, UNITED KINGDOM
Investigate renal drug transport modalities and drug interactions in vitro. aProximate™ PTCs retain high expression of the relevant transporters involved in drug handling including megalin and cubilin; so are ideal for drug transporter and drug interaction studies of both ...
Manufactured by:Puracyp based inCarlsbad, CALIFORNIA (USA)
Screening for nuclear receptor activation is a widely used and accepted practice to predict adverse drug effects and drug-drug interactions. Moreover, assessing nuclear receptor activation meets the latest FDA guidance for industry on Drug-Drug Interactions. Receptor activation ...
Manufactured by:Creative Bioarray based inShirley, NEW YORK (USA)
Pooled Human Hepatocytes are the chief functional cells of the liver, responsible for the selective uptake, metabolism and excretion of most drugs. Cells for use in plate cultures or suspension assays represent a key tool for predicting properties such as hepatotoxicity, metabolism, and potential drug-drug interactions. Since ...
by:InterX based inBerkeley, CALIFORNIA (USA)
InterX operates at the nexus of academic research and pharma-tech industry. We partner with leading edge researchers, drug developers, and biotechnology companies across the globe to predict drug-target interactions using the most advanced computer algorithms ...
by:Center for Toxicology and Environmental Health, L.L.C. (CTEH) based inNorth Little Rock, ARKANSAS (USA)
CTEH®’s pharmacology & toxicology professionals have extensive experience assessing the human toxicity of drugs and chemicals, and drug interactions and adverse reactions. CTEH® provides additional experience in pharmacokinetic analysis. Levels of drugs or chemicals in blood and/or urine are frequently key ...
Manufactured by:Alfa Chemistry based inNew York, NEW YORK (USA)
Early studies on the properties of drugs in ADMET mainly focused on human-derived or humanized tissue functional proteins as drug targets. Combined with in vitro research techniques and computer simulation, scientists study the interaction between drugs and in vivo biophysical and biochemical barrier factors. Alfa Chemistry can ...
Manufactured by:Regis Technologies Inc. based inMorton Grove, ILLINOIS (USA)
HPLC Tools for Drug Membrane Permeability Prediction. IAM Drug Discovery HPLC Column is an ideal tool for high throughput prediction of drug membrane permeability. The results from this column correlate well to traditional in-vitro methods such as intestinal tissue and Caco-2 Cells, yet are faster and cheaper to achieve. ...
by:Helix Diagnostics based inWaterford Twp, MICHIGAN (USA)
Helix Diagnostics pharmacogenomics testing identifies unique variances on gene markers to determine an individual’s response to particular medications to create better treatment plans and improve outcomes. Reviewing patients genetic profile allows a much more personalized medicine approach and eliminates trial and error for more effective, quicker and safer therapies. ...
Manufactured by:BioVariance GmbH based inKonnersreuther Str. 6g, GERMANY
The goal of personalized medicine is to prescribe the most suitable medication in the optimal dosage for each individual patient. To achieve this, physicians rely not only on medical diagnoses that take the personal characteristics of a patient into account but can now also engage modern tools of molecular diagnostics. Such genetic analyses can provide essential information to fully identify the ...
Manufactured by:Invicro, LLC based inNeedham, MASSACHUSETTS (USA)
Invicro’s early clinical imaging services deliver decision-making data for drug development teams in Phases 0, I and II. We have many years of pharma industry experience, and this understanding of the drug development process helps us design and execute pathology and imaging studies so that the resultant data reduces risk in later phases of development. We own and operate clinics in ...
by:AFFINImeter by Software 4 Science Developments based inSantiago de Compostela, SPAIN
Our services and our proprietary software allow us to support decision making in hit validation and lead optimization of drug candidates by Isothermal Titration Calorimetry. ...
Manufactured by:Piramal Pharma Solutions (PPS) based inMumbai, INDIA
In vitro facilities at PDS provide absorption, distribution, metabolism, and excretion (ADME) services for faster and improved decision making points or standalone offering to support drug discovery programs. Cost-efficient, standardized and customized assays for ADME parameters are provided to the ...
Manufactured by:CN Bio based inCambridge, UNITED KINGDOM
Employing our Liver-on-a-chip hepatic co-culture model (evaluated by our collaborators at the U.S. FDA), our DILI in vitro Service can screen your small molecules, antibodies, ASO, and gene editing reagents to establish human DILI ...
Manufactured by:Newcells Biotech Limited based inNewcastle Upon Tyne, UNITED KINGDOM
Cross-species comparison of drug handling with near-physiological kidney transporter model. New drug molecules are usually tested in vivo in two preclinical species to gain a more detailed understanding of how they are transported and eliminated through the kidney and also to mitigate risk of renal toxicity in humans. However, these animal models are not always predictive of human responses. To ...
Manufactured by:Charles River based inHollister, CALIFORNIA (USA)
Discovering and characterizing novel drug candidates for preclinical development depends on innovative and reliable science. Our unique combination of integrated, multidisciplinary drug discovery expertise and unparalleled scope of capabilities in targets, platforms, and therapeutic areas allow us to deliver depth and breadth in science with data and insight you can trust to progress your drug ...
Manufactured by:Creative Bioarray based inShirley, NEW YORK (USA)
Creative Bioarray provides you with patterned cell culture based on Cell Patterning. We aim to control factors such as spatial constraints and chemical exposure in the 3D platform through cell patterning technology to create a specific microenvironment, so as to better study the impact of cell microenvironment on the behavior of cells, tissues or organs and realize high-throughput drug ...
Manufactured by:in.vent Diagnostica GmbH based inBerlin, GERMANY
engine is your reliable partner for the analysis of your sample. Our protein array screening service covers the analysis of positive interactions up to antigen identification. In a single experiment it is possible to screen your sample for interactions with more than 10,000 antigens. Our fast method is non-biased and guarantees maximum outcome. You get your results much faster than with standard ...
Manufactured by:InnoSer Belgie NV based inDiepenbeek, BELGIUM
We optimize your lead compounds using expertise and data-driven decisions. The lead optimization stage marks the end of the drug discovery phase and the start of pharmaceutical or biological development. Insight into the absorption, distribution, metabolism, and excretion (ADME) is key to progressing your identified lead compounds after the hit to lead phase. ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Hydrogen-deuterium exchange mass spectrometry (HDX-MS) is a mass spectrometry (MS) technique that studies protein spatial conformation. In this process, protein hydrogen atoms can exchange with deuterium atoms in heavy water. The hydrogen atoms of amide bonds on the protein surface or those involved in protein-ligand interactions exchange at a faster rate than those deeper within the protein or ...
Manufactured by:Creative Bioarray based inShirley, NEW YORK (USA)
Creative Bioarray provides various in vitro ADME/PK services including high-throughput ADME screening, in vitro metabolism, in vitro permeability and transporter assays. ADME is short for "absorption, distribution, metabolism, and excretion". The four properties determine the drug level within a body, the drug exposure to tissues, and the metabolic process of a compound, which can help predict ...