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Epitope Services
45 services found
Manufactured by:Creative Peptides based inNew York, NEW YORK (USA)
Epitope Mapping is an essential aspect in the discovery and development of diagnostic and therapeutic antibodies. It can aid in the selection of optimized therapeutic MAbs, elucidate cancer-specific epitope markers, and define the protective (and in some cases pathogenic) effects of vaccines. Based on our advanced peptide library platform, Creative Peptides ...
Manufactured by:Sanquin based inAmsterdam, NETHERLANDS
Our proprietary technology for UV-induced MHC-peptide exchange is ideally suited for high-throughput screening of peptide-binding to the MHC class I complexes. Moreover, combinatorial coding enables fast finding of relevant peptide-specific cytotoxic T ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
MtoZ Biolabs has established an innovative EpiLink™ technical platform, which can outline the overall protein architecture via identifying direct binding partners and localizing the binding ...
Manufactured by:POP Biotechnologies, Inc. (POP BIO) based inBuffalo, NEW YORK (USA)
CoPoP GLP toxicity report available. CoPoP is part of EuCorVac-19, tested in a 280 person ph1/2 trial. Testing framework for human ...
Manufactured by:POP Biotechnologies, Inc. (POP BIO) based inBuffalo, NEW YORK (USA)
SNAP liposomes contain synthetic MPLA, QS-21 and Cobalt porphyrin phospholipid (CoPoP). CoPoP enables liposomes to stably bind short MHC-I epitopes upon admixture. Better delivery of epitopes and adjuvants to immune cells in draining lymph nodes. Induce higher frequency of antigen specific CD8+ T cells with > 10,000X lower peptide ...
Manufactured by:Creative Biolabs based inShirley, NEW YORK (USA)
Creative Biolabs provides a comprehensive range of services based on our matured platform, which involves in the custom antibody development service, from antigen design and epitope prediction to antibody purification and labeling. https://modelorg-ab.creative-biolabs.com/monoclonal-antibody-development.htm ...
Manufactured by:Aviva Systems Biology Corporation based inSan Diego, CALIFORNIA (USA)
Surface Plasmon Resonance (SPR) is a powerful analytical technology that is well suited for analyzing and characterizing antibodies. SPR can be used to measure the antibody-antigen binding kinetics, perform epitope binning and epitope mapping. The latter may be used to identify antibody pairs for developing high-precision ELISA or multiplex assays.. Aviva Systems ...
Manufactured by:Absolute Antibody Ltd based inRedcar, UNITED KINGDOM
Binding multiple epitopes with a single antibody offers several benefits. For example, one specificity may target individual molecules while another could recruit effector cells or deliver a drug to the target. Other options include dual-target bispecifics which might detect a desired cell type with much higher selectivity than a monospecific antibody. ...
by:Biointron based inShanghai, CHINA
Nanobodies are distinguished from other conventional antibody formats by their unique properties of size, solubility, intrinsic stability, easy tailoring into pluripotent constructs, recognition of uncommon or hidden epitopes, binding into cavities or active sites of enzyme targets, ease and speed of drug discovery, and ease of manufacture. BioIntron is a well-recognized leader ...
Manufactured by:Antibodies Incorporated based inDavis, CALIFORNIA (USA)
The monoclonal antibodies produced have broad utility as therapeutics, diagnostic tools, and research reagents. The approach enables discovery of antibodies that bind to a variety of epitopes on the target molecule and, coupled with a robust screening platform, allows for identification of clones with the most desirable characteristics. ...
by:Revvity Gene Delivery (formerly SIRION Biotech) based inHamburg, GERMANY
In the discovery of oncology therapeutics, Antibody-drug conjugates (ADCs) are rapidly gaining momentum, with hundreds of candidates advancing through clinical development. Whether your priority lies in assessing the epitope binding of your construct, evaluating the cytotoxic potency of the payload, or scrutinizing the efficacy of the linker in cleaving, each facet demands ...
Manufactured by:Rockland Immunochemicals, Inc. based inLimerick, PENNSYLVANIA (USA)
Our list of services includes antigen consultation, peptide or protein antigen production, antibody generation, antibody purification, and conjugation to reporter molecules such as peroxidase or fluorochromes. We are experts in generating antibodies specific for post-translational modifications—including phospho-epitopes, acetylation, methylation, hydroxylation, ...
Manufactured by:MODAG GmbH based inWendelsheim, GERMANY
The misfolding/ aggregation pathway resulting in amyloid fibrils involves characteristic oligomer species which have been shown to be the most relevant toxic protein species. These pathological oligomers exhibit structural epitopes that are not found in physiologically folded proteins or physiological protein assemblies, providing a specific structural target for anle138b, our ...
Manufactured by:Nexelis based inSeattle, WASHINGTON (USA)
We have exceptional in vitro bioassay development services and support for early evaluation and screening of candidate therapeutics. Our highly experienced team will facilitate in silico immunogenicity assessment with epitope prediction to in vitro immunogenicity and immuno-functionality assays. ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
T cells play a vital role in destroying pathogens and monitoring pathological cells. They are able to distinguish between self-antigens and non-self-antigens by surface T cell receptors (TCRs). Most human T cells express the classical TCRs, which consists of TCRα and TCRβ chains co-expressed with CD3 chains (γ, δ, ε, and ζ). ...
Manufactured by:Fluidic Sciences Ltd based inHertfordshire, UNITED KINGDOM
This technology is crucial for the effective analysis of monoclonal and bispecific antibodies' interactions with epitopes in real-world ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
All cellular protein functions, including those involved in disease processes, require coordinated movements at the atomic or domain level, known as conformational dynamics. Proteins regulate almost all biological processes within living organisms and are the material basis of life activities. Proteins fold into specific three-dimensional structures based on their primary structure (amino acid ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Monoclonal antibodies (mAbs) are powerful therapeutic tools. These glycoproteins, belonging to the immunoglobulin (Ig) family, are utilized by the immune system to identify and neutralize foreign organisms or antigens. Ig’s are classified in five groups, IgA, IgD, IgE, IgG, and IgM (as α, δ, ε, γ, and μ), based on the structure of their constant regions. Among these, IgG subtypes—predominantly ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Structural biology has always played a vital role in drug discovery because it provides the most direct and visible atomic-level information on drug targets and can be applied to every step of preclinical drug development, including target identification and design as well as lead compound optimization. Based on atomic resolution information about the active or regulatory sites of target ...
by:Ab Studio Inc. based inHayward, CALIFORNIA (USA)
3D Computer-aided antibody structure analysis service based on advanced AI protein modeling software (AlphaFold) and antibody design ...