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Genotoxicity Testing Services
9 services found
Manufactured by:Environmental Bio-Detection Products Inc. (EBPI) based inBurlington, ONTARIO (CANADA)
In addition to the specific mutagenicity assays provided by EBPI Analytics, a line of general genotoxicity tests are offered. These assays use modified bacteria that have the induction of a SOS DNA response gene coupled to a gene that expresses a measurable colorimetric endpoint. The degree of induction of the SOS response can be quantified by the degree of ...
Manufactured by:Molecular Biology Resources, Inc. based inMilwaukee, WISCONSIN (USA)
MBR offers assay services to investigate the effects of drug compounds on key DNA replication and repair enzymes, such as human DNA polymerase α (alpha), human DNA polymerase β (beta), human DNA polymerase γ (gamma), and HeLa cell extracts (containing replication protein ...
Manufactured by:CD Formulation based inShirley, NEW YORK (USA)
Genotoxic Impurities Test: The control of genotoxic impurities is a complex and delicate project throughout the whole life cycle of drug development, and an important part of it is the assessment of genotoxic impurities. The study of genotoxic impurities involves a combination of organic chemistry, biochemistry, ...
Manufactured by:Gentronix Ltd based inCheshire, UNITED KINGDOM
The mouse lymphoma assay is one of the mammalian gene mutation assays available and is frequently utilised in most genotoxicity testing regulatory frameworks. Able to detect point mutations, clastogens, and in some cases aneugens; the mouse lymphoma assay has an advantage compared to the HPRT (the alternative mammalian gene mutation assay) due to its capability ...
Manufactured by:Gentronix Ltd based inCheshire, UNITED KINGDOM
The in vitro micronucleus test (MNT) is a main-stay of most regulatory genotoxicity testing strategies, and is used to detect in vitro clastogens and aneugens. In this regard it complements the Ames test well, as between the two study types they detect all of the three major classes of genotoxin. ...
Manufactured by:Creative Bioarray based inShirley, NEW YORK (USA)
S9 stability assay and hepatocyte stability assay are also available at Creative Bioarray. Liver S9 fraction (Cat. CSC-C4093X) as a product can be used in genotoxicity tests such as the Ames test as a metabolic ...
Manufactured by:Gentronix Ltd based inCheshire, UNITED KINGDOM
The Ames test, a bacterial reverse mutation assay, is the most commonly requested genotoxicity study in regulatory testing frameworks and has been in use for decades. The test investigates the ability of test substances to cause specific mutations in Salmonella or E. coli strains that allow them to then grow on ...
Manufactured by:SEQENS Group based inÉcully, FRANCE
Seqens provides GMP testing on Active Pharmaceutical Ingredients (API) and excipients. We have an extensive team focused on the development and clinical phase appropriate validation of sensitive and specific analytical methods. Our analysts work closely with our chemists to develop In Process Control, isolated intermediate, and finish product release and stability indicating ...
by:TÜV SÜD America Inc. based inWakefield, MASSACHUSETTS (USA)
In the medical field, practitioners utilize a range of devices to address patient health, from diagnosis to surgery. When the patient comes into contact with a medical device or material, it should fulfill its intended function without harming the patient. Therefore, all medical devices need to undergo a thorough biological risk assessment to protect the patient from any toxic, physiological, ...