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Multiple Reaction Monitoring (MRM) is a quantitative method for analyzing targeted proteomics. Based on the sequence information of targeted proteins, MRM selectively analyzes proteins correlating with the targeted peptide signals, eliminating signals from interfering peptides. There are three steps in MRM mass spectrometry analysis: isolation of targeted precursor peptides based on MS spectra, fragmentation of precursor peptides, and detection of fragmented ions based on MS/MS spectra.
MRM has the highest accuracy among all proteomics quantitation methods, enabling absolute quantitation of protein with reference to internal standard, and analysis of up to 200 proteins at the same time. MtoZ Biolabs is proud to offer an all-inclusive MRM service. Just tell us your project objective and send us the protein sample, we will perform all the corresponding experiments, and provide the most professional analytical service to meet your specific needs.
AB SCIEX TripleTOF 5600, AB SCIEX Triple Quad™ 5500 and Q Exactive Fusion
1. Isotopic Labels are Not Required
2. Simpler Experimental Procedures and Data Analysis
3. Samples are Run Individually, and Numbers of Samples are Unlimited
4. Suitable for Analyzing Various Types of Samples, Including Tissue, Cell, Blood, etc.
1. Verification of Untargeted Proteomics Results, Such as Label-Free Proteomics
2. Absolute Quantitation of Up to 500 Proteins/Peptides
3. Analysis of Highly Homologous Protein Family Members
4. Protein Post-Translational Modification Analysis
5. Discovery and Absolute Quantitation of Biomarkers
1. Label-Free MS Data Quality Assessment
2. Multivariate PCA Analysis
3. Protein Statistical Analysis: Venn Diagram, Volcano Plot
4. Functional Annotation: GO Annotation, KEGG Annotation, COG Annotation
5. Clustering Analysis: Hierarchical Clustering, K-Means Clustering
6. Network Analysis: STRING Analysis
1. Experiment Procedures
2. Parameters of Liquid Chromatography and Mass Spectrometer
3. MS Raw Data Files
4. Peptide Identifications and Intensities
5. Protein Identifications and Intensities
6. Bioinformatics Analysis
MtoZ Biolabs is an integrate contract research organization (CRO) providing advanced proteomics, metabolomics, bioinformatics, and biopharmaceutical analysis services to researchers in biochemistry, biotechnology, and biopharmaceutical fields. The name of MtoZ represents “mass to charge ratio” in mass spectrometry analysis, as most of our services are provided based on our well-established mass spectrometry platforms. Our services allow for the rapid and efficient development of research projects, including protein analysis, proteomics, and metabolomics programs.
MtoZ Biolabs is specialized in quantitative multiplexed proteomics and metabolomics applications through the establishment of state-of-the-art mass spectrometry platforms, coupled with high-performance liquid chromatography technology. We are committed to developing efficient, and effective tools for addressing core bioinformatics problems. With a continuing focus on quality, MtoZ Biolabs is well equipped to help you with your needs in proteomics, metabolomics, bioinformatics, and biopharmaceutical research. Our ultimate aim is to provide more rapid, high-throughput, and cost-effective analysis, with exceptional data quality and minimal sample.
Email: [email protected]