Oncogene Articles & Analysis
42 articles found
The process of immortalization typically involves the introduction of specific oncogenes or the use of viral vectors to enhance the longevity of the cells. ...
While combustible cigarette smoke (CCS) is a well-established carcinogen, the oncogenic potential of electronic cigarette vapor (ECV) remains underexplored. ...
By studying how these cells respond to oncogenic signals, scientists have been able to identify potential therapeutic targets. ...
In the oncology field, ChiRP Service has revealed how oncogenic lncRNAs like MALAT1 coordinate metastatic programs by assembling specific ribonucleoprotein complexes at chromatin loci controlling epithelial-mesenchymal transition. ...
Applications of CRISPR Library Screening CRISPR library screening has a wide range of applications in various fields, including: Cancer Research In cancer research, CRISPR libraries can be used to identify oncogenes and tumor suppressor genes that contribute to tumorigenesis. ...
Enzyme Induction: Some glucosinolate degradation products, like radish sulfur (4-methylthiooxybutyl glucosinolate), are powerful inducers of detoxifying enzymes that can inactivate oncogenes. The bioavailability and activity of glucosinolates in humans depend on factors such as food preparation methods, gut microbiota composition, and individual metabolic responses. ...
Discover how matched tumor-normal sequencing can help clinical researchers detect the somatic origin of variants with certainty. In the era of precision oncology, it has become increasingly common for patients diagnosed with cancer to undergo tumor sequencing. Identifying the mutations that make up a tumor’s genomic landscape can help guide selection of targeted therapies and inform ...
In response to the emerging needs in global healthcare, SOPHiA GENETICS has just revealed the New Generation SOPHiA DDM™ Platform, aiming to stay at the forefront of precision medicine and address today the healthcare needs of tomorrow. ...
Furthermore, our Gene Overexpression Cell Line Construction Service is not limited to a specific gene or cell type. Whether you are studying oncogenes, tumor suppressor genes, transcription factors, or any other gene of interest, we can assist you in creating stable cell lines with precise control over gene expression levels. ...
This technology has been applied to detect KRAS oncogenic mutations (SNPs). The use of fluorescent PNA probes has also been extended to the detection of triplexes.Supramolecular drugsOver the past decade, many studies have used PNA-ligand conjugates to self-assemble into larger structures. ...
Such residual DNA may have infectious or tumorigenic risks, for example, the residual DNA may carry the HIV virus or the Ras oncogene. Host Cell DNA Testing is a tool to accurately quantify the amount of host cell DNA residues in biologics using qpcr and other methods. ...
Evidence that NF-κB can transform cells originally came from the discovery of the v-Rel gene from an avian retrovirus, which encodes a protein that is highly oncogenic and can cause malignant cancers in chickens. Later studies revealed that the protein encoded by v-Rel belongs to the Rel subfamily of NF-κB, and several other oncogenic viruses that ...
BioID in drug target discovery RAS is an oncogene that is difficult to intervene with drugs. kovals⁃ki et al. combined BioID with CRISPR screening to identify a new set of functional RAS-associated proteins and defined mTORC2 as a direct RAS effector. Interfering with Ras-mTORC2 interactions can weaken RAS-dependent tumorigenesis in vivo, providing a possible option for the ...
The Myc gene is one of the most important drivers of cancer in mice and humans. Myc also plays a newly discovered key role in aging, according to a new study in Cell Reports by researchers at UPMC Children's Hospital of Pittsburgh and the University of Pittsburgh School of Medicine. The study, led by Edward V. Prochownik, MD, UPMC Children's Hematology/Oncology Division and Paul C. Gaffney ...
This approach is highly effective in identifying retroviral integration sites, thus strengthening our understanding of many oncogenic viruses. Additionally, the technique plays a crucial role in investigating unknown DNA segments' origins and studying transposons' mobility, gene modifications, and bacterial adaptability. ...
For instance, rcDNA may carry the HIV virus or the Ras oncogene. The insertion of LINE-1 sequences, found in mammalian cell genomes, into chromosomes as retrotransposons can impact the functionality of essential genes, potentially activating oncogenes or inhibiting tumor suppressor genes. ...
Recently, in a research report entitled "Oncogenic CDK13 mutations impede nuclear RNA surveillance" published in Science, scientists from Howard Hughes Medical Institute and other institutions discovered a new type of mechanism that affects the occurrence of melanoma, providing broad and important implications for the treatment of various cancer patients. ...
For example, off-target effects of gene editing can lead to unintended consequences, such as the activation of oncogenes or disruption of normal gene function. In conclusion, DNA modifying enzymes play an essential role in maintaining the integrity and expression of genetic information. ...
Subsequently, multiple types of ALK gene rearrangements were identified in NSCLC, diffuse large B-cell lymphoma, and inflammatory myofibroblastic tumor (IMT) respectively, proving ALK to be a potent oncogenic driver. Researchers developed a retroviral cDNA expression library to screen for novel oncogenes. ...
The proliferation of pancreatic ductal adenocarcinoma (PDAC, the most common pathological type in pancreatic cancer) with mutations in the oncogene Kras is highly dependent on the glutamine (Gln) catabolic pathway. ...