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Mass Spectrometry Coupling Services
361 services found
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
MtoZ Biolabs has developed a high-resolution mass spectrometry, coupled with pLink-SS software, to provide our customers with accurate analysis of disulfide bonds and free ...
by:Adirondack Environmental Services Inc. based inAlbany, NEW YORK (USA)
Digital imaging providing QIA (Quantitative Image Analysis) for specialized techniques including automated particle size distribution, colorized elemental x-ray mapping and Stereo/3D imaging and email digital image reports. Gas Chromatography and Gas Chromatography Mass Spectrometry, Inductively Coupled Plasma (ICP) Analysis, Full Wet Chemisty ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
The COG (Clusters of Orthologous Groups) database is an early and widely used resource for the homologous classification of gene products, based on extensive comparisons of protein sequences from various ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Data completeness and accuracy is crucial for subsequent statistical and biological results. After verifying the experimental design and the accuracy of the collected data, MtoZ Biolabs conducts an initial integrity check. This involves removing or imputing missing values, excluding outliers, and normalizing data across samples and metabolites to allow for parallel comparisons. Metabolites with ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
In contrast to principal component analysis (PCA), both partial least squares discrimination analysis (PLS-DA) and orthogonal PLS-DA (OPLS-DA) are supervised statistical methods for discriminative analysis. These methods develop models that correlate metabolite expression levels with sample categories to facilitate prediction of the category of ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
In top-down proteomics analysis, intact protein molecular ions generated by ESI or MALDI are introduced into a mass analyzer and undergo gas-phase fragmentation. Top-down analysis facilitates the direct observation of C-terminal and N-terminal truncations and the differentiation of isomers through different ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
During the comparative analysis of metabolites between two sample groups, commonly employed univariate methods include Fold Change Analysis (FC Analysis), the T-test, and the Volcano Plot, which synthesizes the preceding two methodologies. This analysis visually elucidates the significance of metabolite variations between samples, aiding in the identification of potential biomarkers (typically ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
To validate the selection of differentially expressed proteins or characteristic differentially expressed proteins, cluster analysis can be performed to group proteins based on expression trends, facilitating more intuitive proteomic data analysis. Services at MtoZ Biolabs 1. Hierarchical Cluster Analysis 2. K-means Cluster ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Glycosylation is an important post-translational modification of proteins. Based on the different linkage modes between the glycan and peptide chains, protein glycosylation can be divided into N-glycosylation and O-glycosylation. N-glycosylation involves the linkage between the reducing end of N-acetylglucosamine (GlcNAc) and the nitrogen atoms on certain asparagine (Asn) side chain amides in the ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
MtoZ Biolabs applies MBRole to enrich metabolic pathways using the differential metabolites, with the KEGG database serving as the reference. The analysis includes all metabolites identified within the same species, focusing on pathways with P < 0.05. Figures 1 and 2 illustrate the types of metabolic pathway diagrams available. These figures depict enriched pathways along with the results of ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Charge heterogeneity is a key attribute of biomolecules such as antibody, enzyme, and protein, affecting the molecule's stability, solubility, and biological activity. Changes of deamidation, oxidation, glycosylation, glycation, the N- or C-terminal, loss of three-dimensional structure, or reduction of disulfide bonds may lead to changes in charge heterogeneity. Since charge heterogeneity ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
The primary structure of proteins is fundamental to the biological function of proteins, and determining the primary structure aids in studying the function of proteins. MtoZ Biolabs provides protein primary structure detection service based on mass ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Sphingosine (SPH) is a long-chain aliphatic compound with an acyclic carbon skeleton, typically featuring a 2-amino-1,3-diol functional group. The primary SPH in mammalian tissues are sphingosine (2S,3R-d-erythro-2-amino-1,3-octadec-4E-ene-diol), sphinganine (2S,3R-d-erythro-2-amino-1,3-octadecane diol), and 4-hydroxy-sphinganine (2S,3S,4R-erythro-2-amino-1,3,4-octadecanetriol). In yeast, the ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Glycerophospholipids are phospholipids based on glycerol, serving as the main components of biological membranes. The diversity of head groups, complex acyl chain combinations, and a broad range of ionization efficiencies pose significant challenges for the accurate quantification of glycerophospholipids. These compounds encompass hundreds of analytes commonly encountered in routine analysis and ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Peptide purity is defined as the ratio of the target peptide to all analytes, essentially reflecting the proportion of the target peptide to impurities. It is typically determined using HPLC analysis at 220nm, the peak absorption wavelength for peptide bonds. The purity of peptides critically influences research outcomes, with potential contaminants arising during chemical synthesis, culturing, ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
The Gene Ontology (GO) is a database created by the Gene Ontology Consortium to provide a standardized vocabulary for gene and protein functions across species, which evolves with ongoing research. It uses a dynamic controlled vocabulary to describe the roles of genes and proteins within cells, offering a comprehensive description of gene and gene product ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
STRING is a database that records predicted and experimentally validated protein-protein interactions (PPIs) across multiple species, including direct physical interactions and indirect functional associations. By integrating the results of differential expression analysis and the interaction pairs recorded in the database, a differential expression protein interaction network is constructed. ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Proteomics mass spectrometry data is fundamental to proteomics analysis. The quality of the mass spectra is closely related to the accuracy of the retrieval and analysis results. Therefore, the quality assessment of proteomics data is particularly important. To ensure the reliability of bioinformatics analysis, MtoZ Biolabs evaluates the identified proteomic data from the following four ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
In scientific research, there are two main types of analysis: qualitative and quantitative analysis. Between qualitative and quantitative analysis, there is a semi-quantitative analysis, which yields approximate measurement value rather than precise one. Semi-quantitative analysis is often used when direct measurement of results is challenging while the conclusions drawn from inference are ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Glycosylation analysis is one of the most challenging types of post-translational modification (PTM) analysis. Glycosylation modifications typically occur at the group level rather than as individual modifications. Even a single glycosylation site on a protein may exhibit various chain lengths and multiple polysaccharide isomers with different branching. ...